Results
| PMID | 24411031 |
| Gene Name | CYP19A1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | CYP19 (rs8042086) |
| Population size | 292 |
| Population details | 292 (121 patients with advanced stage endometriosis, 171 control women) |
| Age | Patients: 30.9 +/-6.3yrs; Controls: 29.1 +/-4.3 yrs |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | HSD17B1, HSD17B2, HSD17B5, HSD17B6, CYP17, CYP19, ER?, ER?, and PGR |
| Other associated phenotypes |
Endometriosis |
|
Taiwan J Obstet Gynecol. 2013 Dec;52(4):485-92. doi: 10.1016/j.tjog.2013.10.006. Wu, Cheng-Hsuan| Yang, Jyuer-Ger| Chang, Yu-Jun| Hsu, Chao-Chin| Kuo, Pao-Lin Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.| Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.| OBJECTIVE: To establish a multilocus model for studying the effect of steroid-related genes on advanced stage endometriosis. MATERIALS AND METHODS: A total of 121 patients with advanced stage endometriosis and 171 control women were included. Eighteen single-nucleotide polymorphisms (SNPs) from nine genes (HSD17B1, HSD17B2, HSD17B5, HSD17B6, CYP17, CYP19, ERalpha, ERbeta, and PGR) were genotyped using the TaqMan assays. Logistic regression models were used to evaluate the genetic effects, with adjustment for other covariates. RESULTS: Only the presence of the mutant CYP19 (aromatase gene) was associated with a significantly increased risk of endometriosis after adjusting for age, BMI, and parity (p = 0.002, OR = 2.69; 95% CI = 1.44-5.02). No association was ascertained between the other investigated SNPs and endometriosis. CONCLUSION: Polymorphisms of the aromatase gene confer susceptibility to advanced stage endometriosis in the Taiwanese Han population. Mesh Terms: 3-Hydroxysteroid Dehydrogenases/genetics| Adult| Aromatase/*genetics| Asian Continental Ancestry Group/*genetics| Case-Control Studies| Endometriosis/ethnology/*genetics| Estradiol Dehydrogenases/genetics| Estrogen Receptor alpha/genetics| Estroge |
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